Skin Microbiome: Perspectives on Aging, Compromised Skin and Cosmetics
15jun(jun 15)8:30 AM22(jun 22)11:45 PM
Event Details
Agenda
Dr. Raja Sivamani
Director of Clinical Research
Department of Dermatology at the University of California
“The gut-skin connection and its relation to acne”
Aleks Richards
Senior R&D Manager at Nutrafol
“The gut microbiome and the hair follicle”
Carl- D’Ruiz
Senior Manager of North American Regulatory and Governmental Affairs for Personal Care Products
DSM Nutritional Products, LLC.
“Fresh insights into the skin microbiome and product claims essentials”
Patrick Gonry
Safety Assessor
Gobiotics
“The influence of cosmetic ingredients on the skin microbiota”
Professor Matthew J. Hardman
Chair in Wound Healing – Hull York Medical School
Director of Research – Hull York Medical School
“The host-microbiota axis in skin aging and repair”
Sponsored by:
Carl D’Ruiz, MPH
Abstract: Fresh insights into the skin microbiome and product claims essentials
Support of microbiome product innovation from a regulatory, safety and claims perspective is essential for helping emerging skin microbiome technologies and products make the leap from trend to established business categories. Discussion will focus on the challenges associated the rapidly moving evolving science of the microbiome and the need to establish reliable scientific data that validates and substantiates the safety, efficacy and claims associated with skin microbiome based products. A clear understanding of the existing and applicable regulatory frameworks governing these products based on intended use will also provide direction and clarity on how to provide consistent and clear product claims and messaging based on strong clinical and scientific evidence.
Bio
Mr. D’Ruiz is an accomplished regulatory leader with more than 20 years of experience in providing scientific and regulatory strategic direction for the global development, marketing, and sustainability of consumer and professional product brands. He has held key R&D, regulatory, quality, clinical and scientific affairs positions at Ciba, Dial, Henkel, Newell Rubbermaid and currently is the Senior Manager of Regulatory and Governmental Affairs for Personal Care Products, NA at DSM Nutritional Products, LLC. He is regarded as a thought leader within the industry on the subject of topical OTC drugs, cosmetics and personal care products and specializes in public health, regulatory and scientific issues associated with topical sunscreens, antimicrobials and skin cancer prevention. He is currently championing industry’s efforts to substantiate the safety and efficacy of existing sunscreens and also paving the path for the inclusion of new sunscreen ingredients under FDA’s OTC sunscreen monograph. Furthermore, he is also active in helping shape and influence key regulatory, legislative and scientific initiatives associated with emerging microbiome and CBD technologies and has a unique flair for developing and substantiating creative, truthful and cutting-edge consumer product label and advertising claims.
Mr. D’Ruiz holds a master’s degree in Human and Environmental Health Science and Risk Management from Yale University and a bachelor’s degree in Political Science and Biology from Fordham University. He also holds executive business certifications in bargaining, negotiations and strategic finance and marketing from The Darden and Wharton Business Schools. He is a full member of the Society of Toxicology.
Prof Mat Hardman. Chair in wound healing & Director of Research, Hull York Medical School, UK.
Abstract: The host-microbiota axis in skin ageing and repair
Our skin is “home” to a multitude of microorganisms, collectively termed the skin microbiota. While existing studies have meticulously explored the role of gut microbiota in health and disease, far less information is available on the significance of skin microbiota in physiology and pathology. Amidst the demographics of an ageing population, age is a well-known contributory factor to skin disease, poor acute healing and a primary risk factor in the aetiology of chronic wounds. Research in this area has historically focused on the contribution of structural and functional changes in the skin (host tissue) to pathology, while age-associated changes in the skin microbiota have been largely ignored. Research from our group and others has highlighted the extensive cross-talk between the skin microbiota and host skin cell, which ultimately directs skin physiology. In this talk I will provide an update on current understanding of the contribution of skin microorganisms to skin biology and pathology. I will focus on the effects of ageing and diabetes on skin function, and dysfunction (including ineffective repair). I will argue that successful development of effective interventions in this area will require a detailed understanding of the host-microbiota axis, underpinned by emerging “omics” and powerful new sequencing technologies.
Bio
Professor Mat Hardman is “Chair in Skin Biology & Wound Repair” and “Director of Research” at the Hull York Medical School (UK). He has 25 years’ experience in the field of skin biology, with a specific focus on skin ageing and wound healing. Mat trained at the University of Manchester (UK) where he was one of only two researchers nationally to be awarded consecutive Junior and Senior AgeUK Fellowships in Ageing research. He established his own research group in 2007, promoted to Reader in 2016. Mat is former Director of the Manchester EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine, and spent 3 years as Research Director in the School of Life Sciences. Current interests in the group include: exploring the complex interactions between the skin microbiota and host response, particularly in the context of ageing wound repair; characterising the effects of ageing and menopause on skin structure and function; exploring the role of hair follicles and stem cells in skin biology & repair; and developing more predictive pre-clinical models for skin & wound research.
Aleksander Richards
Abstract: The gut microbiome and the hair follicle
The gut is the mirror to one’s overall health. There are many organ systems that the gut microbiota can influence and exert their effects on. From axis such as the gut-liver, gut-skin, gut-hair, and gut- thyroid the intestinal bacteria control our health destiny. The largest nerve in the body, the Vagus Nerve, has an activation in the microbiome which can subsequently send electrical signals that promote anti-inflammatory and cortisol reduction pathways. These pathway control hair growth cycle as well. Furthermore, gut inflammation can increase the space between gap junctions, increase intestinal permeability, and decrease bacterial adhesion to the intestinal lining all of which reduce nutrient absorption. Nutrients such as iodine, selenium, and the absorption of nutraceuticals are integral for maintaining a proper hair growth cycle. These actives and minerals subsequently influence the thyroid, the liver, and the adrenals in a manner that is integral to one’s hair growth. This is just one of the many pathways I will describe that show how crucial a healthy and varied microbiome is for one’s hair health and wellness.
Bio
Aleks Richards graduated from Fordham University in 2016 with a bachelor’s degree in Biology and Pre-Med. He is currently Senior R&D Manager at Nutrafol, a company specialized in treating hair loss and thinning using nutraceuticals. Aleks has been involved earlier on in the formulation of Nutrafol leading products. He currently leads the biology research team focusing on specific and novel pathways relating to hair loss. The microbiome has been a focus of his research and he contributed in the formulation of specific probiotics to target hair loss and thinning.
Raja Sivamani
Abstract: The gut-skin connection and its relation to acne
Research into how gut health affects the skin and the concept of the gut-skin axis has led to the growth in the concept of “healthy from within” and “beauty from within.” This concept has now being applied to acne which has previously focused largely on antibiotics and retinoids as a backbone of treatment. The discovery of the gut-skin axis has been disruptive in this field as we learned how the gut microbiome and gut related signaling mediators may influence acne. Different factors involved in the gut-skin axis in relation to acne will be discussed including the role of nutrition, the role of shifts in the gut microbiome, and associated changes in gut derived signals that can reach the skin.
Bio
Dr. Raja Sivamani is a board-certified dermatologist as well as an Ayurvedic Practitioner and hosts the wellness platform Jivome and has two clinics Pacific Skin Institute and Zen Dermatology. His the Director of Clinical research in the Department of Dermatology at the University of California, Davis and he is the Co-Director of the Microbiome Research Initiative at the California State University, Sacramento. He focuses on general and integrative dermatology including medical, surgical, and cosmetic services with training in bioengineering, Allopathic and Ayurvedic medicine. He merges modern research and science with a personalized approach to each patient. His training in Ayurvedic medicine lets him take a more humanistic approach to patient care, science, and research. Dr. Sivamani has over 110 peer-reviewed publications and a textbook on cosmeceuticals. He leads many clinical studies that focus on the impacts of foods, nutrition, the microbiome, and the gut-skin axis as well as studies on standard Western medications and devices. Finally, he is a deep believer in integrative medical education and one of the main editors for LearnSkin.com.
Patrick Gonry
Abstract: The influence of cosmetic ingredients on the skin microbiota
A discovery presentation to the external influences on the skin microbiota. The following influences are demonstrated:
- Temperature
- UV
- The use of cosmetics
The surprising effect of cosmetic ingredients on the balance and diversity of the skin microbiota is demonstrated In-vivo. Following ingredients have been studied:
- water,
- alcohol,
- preservatives,
- surfactants,
- emulsifiers
- …
Based on these results an attempt to define a balanced skin microbiota and a healthy diversity is proposed. Special attention is also given to intimate and oral microbiota.
Bio
He graduated as a chemical engineer at the University of Ghent, Belgium in ‘91. Afterwards, he finished an intensive specialisation in cosmetic manufacturing and obtained a degree in dermato-cosmetic science at the medical University of Brussels.
In 2001 he started the consultancy company S&C, supporting cosmetic producers and raw material suppliers in product development, global legislation and toxicology. He trained many cosmetic chemists and technical sales representatives. Since 2002 his research and passion are dedicated to the skin microbiota, which resulted in the launch of the first prebiotic ingredient dedicated to baby care and intimate hygiene. He is the driving force behind many skin microbiota cosmetics in Europe. Through his latest company Gobiotics-Ingredients he offers the industry scientific solutions to support skin microbiota claims.
A determined scientist with concrete solutions and a heart for the invisible world on our skin.
Co-Chairs/Moderators:
Sarah de Szalay
R&D Manager Hygiene Personal Care
RB
Aysel Calkap
Business Development Manager
DSM
Sarah de Szalay is currently Category R&D Manager for Personal Care at RB where she has worked since 2009. She has more than 25 years of experience in Consumer Goods having also worked at companies like Avon and Unilever. Her key focus areas include front end / upstream innovation, formulation development, methods development and technology development as well as the development of partnerships with Key Opinion Leaders and universities. Over the course of her time in the industry, she has developed well over 100+ products including OTCs, regulated products and cosmetics. Currently she focuses on clinical study development and new formula development to evaluate the impacts of topical products and actives on the skin microbiome and skin barrier.
Sarah is an inventor on several patents and has co-authored book chapters and peer-reviewed publications. She has also been a critical reviewer on peer-reviewed journals and a speaker at conferences.
Sarah has a BS and an MS in Chemical Engineering from Manhattan College and is an active member of the NYSCC. Since 2018 she volunteers for the NYSCC as an event coordinator and co-chair for the annual meeting focused on microbiome.
Aysel Calkap, co-chair of the NYSCC Microbiome event, has leveraged her 20+ years of microbiology experience to support the creation of this event. Aysel has a Masters of Science in Microbiology and has led and developed microbiology efforts at organizations including Nestle, Troy, Symrise and Lonza. Aysel is currently Business Development Manager for DSM Personal Care and in her role supports the development of DSM’s global microbiome platform.